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BDBT is a protein whose association with DBT is necessary for circadian rhythms, and it is regulated by both light and circadian rhythms in the eye Bride of DBT (BDBT) was discovered by our lab in a proteomic screen for factors that associate with the principal circadian kinase DBT (hence the name), and it is required for normal DBT activity on PER protein (stimulation of DBT activity, Figure 1

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Researchers investigate its role in protecting cellular components from oxidative damage, supporting glutathione-dependent enzymes, and regulating signaling pathways involved in cellular homeostasis and mitochondrial function

High doses of Vitamin B6, i.e