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Dismissing such studies in favor of lower-quality evidence with greater potential for bias represents a fundamental rejection of evidence-based principles (Guyatt et al., 2008[47]

In their later study, Vaillancourt and his colleagues demonstrated that 4-HNE was cytotoxic and could induce apoptosis in human osteoarthritic chondrocytes [84]

doi: 10.3168/jds.2016-11812 255 ZhaoFWuTZhangHLoorJJWangMPengAet al

Researchers commonly use 1mL or 2mL of bacteriostatic water

& Meyaard, L

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