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Its done most often intravenously or subcutaneously

10.1177/11786361231162720 8 AndoR.HirookaK.SaitoM.KaseS.NodaK.IshidaS

[DOI] [PMC free article] [PubMed] [Google Scholar] 151.Diabetes Canada Clinical Practice Guidelines Expert Committee, Bril V, Breiner A, Perkins BA & Zochodne D Neuropathy

Several trials and updated analyses indicate improvements in fasting insulin, HOMA-IR, BMI/waist indices, and lipid parameters, particularly among women with obesity or IR and low baseline 25(OH)D, whereas pooled estimates from other RCTs fail to show consistent effects on fasting glucose or HOMA-IR, likely reflecting underpowered studies and short follow-up (118)

The numbers speak for themselves

Insulin-like growth factor binding proteins review