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Results versus placebo: ALT decreased 25%, AST decreased 17%, fasting glucose decreased 6%

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Although exogenous stem/progenitor cell transplantation is considered a potential strategy for treating intervertebral disc degeneration (IVDD), its efficacy is severely constrained by the aforementioned microenvironment

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However, absence of thorough human clinical trial data means some uncertainty remains regarding long-term safety

FIGURE 1 3 Current treatments The first-line treatment options for symptomatic LDDD include the administration of medications, such as non-steroidal anti-inflammatory drugs, muscle relaxants, and opioids, to alleviate pain (Otsuki et al., 2023