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doi: 10.1079/9781780642635.0390 13 BackK

Biomolecules 12 , 1227 (2022)

doi: 10.1371/journal.pone.0257843

As detailed in Sections Historical perspective and milestone events in protein folding and Causes and consequences of protein misfolding of this Review, complementary experimental and computational approaches have provided major insights into folding mechanics and proteostasis under normal physiology

The latter is defined as imbalance of reactive dicarbonyl glycating agents and enzyme activities leading to increased protein glycation 8

In a randomized trial (NCT01238926), PD patients were assigned to one of four groups: vitamin supplementation (5 mg/day folic acid, 2,000 mcg/day vitamin B12, and 5 mg/day vitamin B6), exercise intervention, a combination of vitamin supplementation and exercise, or no intervention