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These enzymes are often upregulated in obesity and metabolic dysfunction

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Amy Yasko talks ( about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12: What is Hydroxy B12

The technique is learnable, but the decisions around it (do you actually need it, what dose, how often, and is something else being missed) are medical judgements, and getting them wrong carries real cost

Common examples include pseudoephedrine causing amphetamine positives or poppy seed consumption affecting opiate results

If the goal is scale weight, this is not the right tool
