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For persons receiving 16 weeks of therapy, additional hepatic laboratory testing should be performed at treatment week 12 (Zepatier prescribing information, 2021)

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Natural folate is predominantly converted to its bioactive form, 5-methyltetrahydrofolate (5-MTHF), in the digestive system, allowing it to be readily used by the body

An initial study suggested that neuron-specific Gpx4 depletion caused neurodegeneration, suggesting the possible involvement of ferroptosis in various neurodegenerative diseases, such as Alzheimers disease (AD) and Parkinsons disease (PD) 19

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