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Although significant progress has been made in studying the TME, precise identification and mechanistic understanding of its components and their influence on cancer cell ferroptosis remain largely unknown

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These ROS are capable of causing uncontrolled oxidation of various cellular components that can lead to oxidative damage of the cell (Asada, 2001

Cu regulation of endothelial cells (ECs) The regulatory action of Cu on ECs, as depicted in Figure 4, promotes angiogenesis

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Addition of an amino group to the N-terminal of Dihexa also attenuates the protective response, suggesting that even small substitutions greatly alter the specificity of Dihexa for its target