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An initial inflammatory response leads to the release of cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-1 (IL-1), and interleukin-6 (IL-6), which stimulate keratinocyte proliferation and epidermal thickening

doi: 10.1056/NEJMoa1712191, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 49.Emdin CA, Haas ME, Khera AV, Aragam K, Chaffin M, Klarin D, et al

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One of the most compelling aspects of Pycnogenol for patients experiencing severe brain fog is its ability to cross the blood-brain barrier and exert direct neuroprotective effects

This may be particularly helpful to those who received the J&J vaccine