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Older adults: Aging can reduce the body's ability to absorb B12, even with a good diet

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This was originally shown in Wallerian degeneration slow ( Wld s ) mice, which are protected from axonal degeneration, showing absence of SARM1 expression 144 and higher neuronal NAD + levels, owing to the overexpression of a chimeric fusion protein of NMNAT1, which allows its redistribution from the nucleus to the axon, where it can substitute for the activity of NMNAT2 (REFS 145,146 )