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According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, close monitoring for cholelithiasis is recommended during weight loss therapy, regardless of modality

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Regardless, the reproduction of L -2HG in the cytosolic compartment is difficult to eliminate, and its persistence can lead to the aggressive reprogramming of metabolism to fuel uncontrolled cancer cell proliferation

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The capsule format is particularly well-suited for small-molecule analogues such as 5-Amino-1MQ

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