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doi: 10.1016/j.appet.2025.107938 [DOI] [PubMed] [Google Scholar] 92.Wu H, Gu Y, Meng G, Zhang Q, Liu L, Zhang S, et al

Botelho, I.M.B., Moura, N.A., Silva, C.A., Tambascia, M.A., Alegre, S.M., Zantut-Wittmann, D.E

GLP-1 can stimulate pancreatic -cells to release insulin

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This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment

1063,1064 Therefore, limiting lipid elevation may have anti-tumor effects, but conclusive data from more preclinical models are needed