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Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)

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13 Also, recent proteomic studies have revealed that NNMT expression in the metastasis-associated stroma is critical for the differentiation of cancer-associated fibroblasts (CAF), cancer migration, and metastasis in ovarian cancer