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Take-home message For the purpose of evaluating anti-aging treatments, the ideal biological clock should be created with these two techniques: It should be trained on historic samples where mortality data is available, rather than current samples where all we know is chronological age, and Components should be chosen by hand to assure all are upstream causes of aging rather than downstream responses to damage

Measuring the ratio of reduced to oxidized glutathione (GSH/GSSG ratio) is a way to determine how such compounds alter the redox potential in the cell

In vivo genotoxicity assessment of sertraline by using alkaline comet assay and the cytokinesisblock micronucleus assay

10.1016/j.jdiacomp.2016.02.003 48 TownsendD

They do not suppress natural testosterone production

Earlier studies found rare, functional mutations in genes encoding for NRXN1, SHANK3, and SHANK2, all of which are proteins that affect the functioning of synapses and have been linked to other, known genetic disorders ( Table 1 Genetic biomarkers in ASD (see text for references)