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therefore, MK-677 does not cause testicular atrophy (shrinkage) or require post-cycle therapy (PCT)

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In order to improve the LBD dimer interface stability, an aspartate residue (D759) present at the LBD dimer interface is mutated to glycine to neutralize the electrostatic repulsion between Asp759 and Asp730 of each GluK3 subunit which are in close proximity to Asp730 and Asp759 from the partner protomer

Similarly, pregnant or breastfeeding individuals should avoid use given unknown effects on fetal development

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ResearchGate preprint