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Efficacy: what the primary endpoint showed Nerandomilast produced a statistically significant but modest reduction in annual FVC decline vs placebo (roughly 6070 mL difference)

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In DSS and TNBS induced colitis models, orally administered KPV has consistently reduced disease activity scores, lowered inflammatory cytokine levels, decreased mucosal damage, and helped restore gut barrier function

However, curcumins anti-inflammatory properties may also fight against autoimmune diseases like Hashimotos