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Therapeutic strategy targeting GSH synthesis has been developed, however, failed to produce desirable effects in preventing cancer progression

Typically follow up injections would be advised at either 8, 10 or more commonly 12 weeks

Specifically, the HgS coordination from the C124 and/or C132 residues can lead to the formation of an adduct between the enzyme and the Hg species, inhibiting the enzyme due to the denaturation of the active site, as depicted in Figure 11

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Additionally, GGCT knockdown concomitantly reduced 5- oxoproline (5-OP) levels in MHCC97H cells, consistent with 5-OP being the direct enzymatic product of GGCT activity, and exogenous 5-OP rescued proliferation under Gln-deprived conditions (Fig

Funding This paper was supported by San Matteo Hospital Foundation, Internal Medicine research fundings, PRIN2017. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest