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doi: 10.1074/jbc.RA117.000826

GSH is synthesized via two ATP-dependent enzymatic steps catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthetase

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IL-1 receptor-antagonist (IL-1Ra) knockout mice show anxiety-like behavior by aging

Taken together, the above findings are supportive of the hypotheses of increased oxidative stress, inflammation and impaired oxidative energy metabolism in ME/CFS