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Hepatic stellate cells had upregulated NNMT expression and altered H3K27 methylation status, which affected the N6-methyladenosine (m6A) of CD44, consequently contributing to the formation of the splice variant CD44v3, which is closely related to tumor metastasis
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However, if vitamin B 12 deficiency is the cause, it will persist despite the resolution of the anemia
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Cellular NAD
