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In a small study involving older individuals, two weeks of supplementation with a combination of N-acety-l-cysteine (NAC) and glycine raised red blood cell (RBC) glutathione levels more effectively than either amino acid alone (Guthikonda, et al American Geriatrics Society,Annual Scientific Meeting, 2006.)

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These short time frames are particularly limiting for processes such as sarcopenia progression and neuroimmune remodeling, which typically require longer observation windows

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Reduction of glutathionylated proteins (PSSG) by monothiol mechanism [[31], [32], [33]] (active site CXXS, Fig