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It is just better systems thinking

Given these limitations, Tesoriere et al

Since members of the glucose transporter (GLUT) family, such as GLUT1 and GLUT3, are widely expressed in normal tissues, including the brain and red blood cells, non-selective inhibition of their activities can lead to systemic hypoglycemia and tissue energy depletion

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Dysfunction of key astrocytic molecular systems, such as those mediated by the EAAT2, AQP4, and purinergic receptors, contributes to neurodegenerative and neurological diseases, including AD, ALS, epilepsy, MS, and sleep fragmentationassociated pathology