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Two multicenter, randomized, double-blind, placebo-controlled Phase III trials enrolled 168 patients with EPP across the United States and European Union

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The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males

Vagner J, Steiniche T, Stougaard M

Fitzpatrick Type III users require 1014 days at 0.25mg daily to see noticeable darkening, while Type IIIIV users often observe results within 58 days