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Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

Relying on melatonin receptor 1B (MT2) can protect neurons, but in Fth-specific knockout mice, melatonin protection was essentially abolished

The Kuceki study builds on this by adding dutasteride and copper peptides and using a tattoo machine for more precise delivery
doi: 10.1249/MSS.0000000000001598 52

Nanoparticles can be designed to respond to specific stimuli, such as pH, temperature, or enzymes, to trigger the release of encapsulated peptides

Manhes AC, Guthierrez MCS, Filgueiras CC, Abreu-Villaa Y
