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It reshapes the gut microbiota structure and activates the GLP-1/GLP-1R pathway, thereby reducing amyloid deposition, enhancing synaptic plasticity, and alleviating cognitive dysfunction ( Lactobacillus reuteri , were closely correlated with cognitive performance in the mice, further highlighting the importance of gut microbiota in the anti-AD effects of TCM (Li Z

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EPIGENETIC REGULATORS AND THEIR METABOLIC FOOTPRINTS Beyond signal transduction drivers, mutational inactivation or neomorphic activation of epigenetic regulatory proteins contributes substantially to well-defined metabolic footprints that characterize specific AML subsets [9,27,28]