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however, trial participants may be randomised in a 2:1 or 3:1 ratio for reasons including cost, ethics, increased statistical power, and the potential to gain extra information on the treatment [15, 19]
It remains an active subject of interest in circadian rhythm and neuroendocrine research
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Schonkeren SL, Thijssen MS, Vaes N, Boesmans W, Melotte V
