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The exact signaling pathway of PPAR in UF has not been clearly characterized despite the fact that PPAR protein isoforms are expressed at higher levels in UF (Tsibris et al., 1999) or a relatively equal level as compared to the normal myometrium (Houston et al., 2003)

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Huperzine A combined with hyperbaric oxygen has a synergistic effect on improved cognitive function and reduced serum hypoxia-inducible factor-1 (HIF-1) levels in elderly patients with vascular dementia, suggested enhanced neuroprotection and improved cerebral oxygenation [6]