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HermelMSweeneyMNiY-MBonakdarRTriffonDSuharCet alNatural supplements for COVID19background, rationale, and clinical trials

Core pathway: melatonin suppression and HPO axis dysregulation Melatonin, a critical hormone produced by the pineal gland during nighttime, is profoundly influenced by environmental light cycles, with levels markedly increasing during the night and decreasing throughout the day

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10.3390/ph13030046 Pharmaceuticals (Basel, Switzerland) 58 SimunkovaM.AlwaselS.AlhazzaI.JomovaK.KollarV.RuskoM.et al (2019)

Additionally, these findings have yet to be consistently replicated across independent cohorts