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NAC did not enhance GSH nor cysteine in venous cord blood, possibly due to either adequate maternal GSH levels at enrollment, or to an effect too transient to be detected at time of delivery

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Reliable imaging tools such as magnetic resonance spectroscopy (MRS) now allow real-time measurement of brain GSH levels, facilitating early detection and therapeutic monitoring

In light of this data, FGF21 stands out as an important hepatokine for both diagnostic and therapeutic purposes in MASLD, particularly for early diagnosis, monitoring disease progression, and targeting treatment [237]

Current research on the role of the gutbone axis in osteoporosis mainly targets the regulation of bone metabolism by intestinal factors, the pathogenesis and therapeutics of osteoporosis, and the interaction of the gutbone axis with other systems