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Gobeil, S., Zhu, X., Doillon, C

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Nuclear DAF-16::GFP was detected in ~40% and ~23% of the worms in fat-6 RNAi-treated glp-1(-) and fem-3(-) worms, respectively, compared to ~90% in control RNAi-treated worms (Supplementary Figs

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This produces tolerance subjects require progressively higher doses to maintain pigmentation, which increases off-target side effect risk