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These findings were confirmed in vivo, in nude mice bearing U937 tumours coinjected with recombinant hGH and the NF-B -inducing anticancer drug daunorubicin, to avoid the in vivo toxicity of TNF-

This review systematically integrates the critical role of glutamine metabolism in tumor development and therapeutic resistance, providing new perspectives and translational pathways for the development of precision therapeutic strategy selection based on metabolic plasticity modulation.