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doi: 10.1146/annurev 17 TangDChenXKangRKroemerG

CUMS depression model mice treated with the compound Chinese medicine XiaoYao San for 2 weeks showed a decrease in hippocampal body weight, total iron, and ferrous iron content

In fact, EDCs may not have the ability to modify DNA sequence but can alter the DNA methylation patterns, induce histone modification and miRNA regulation leading to transcriptional changes associated with different diseases such as hormone production disruption (Figure 3), affecting neuroendocrine system dysfunction (142), prostate carcinogenesis process (95), change in behavior responses (73), and tumor formation in second generation (F2) mice (143, 144)

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Gliotoxin was firstly isolated from A