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Conventional glutathione shows limited intracellular delivery due to instability before systemic circulation

doi: 10.1159/000489241 139 XiaC.MengQ.LiuL.-Z.RojanasakulY.WangX.-R.JiangB.-H

Similar content being viewed by others Background The use of oxygen by aerobic organisms in several metabolic reactions has the side effect of the toxicity associated with oxygen by-products such as hydrogen peroxide (H 2 O 2 )

A., Suryanarayana, P., Putcha, U

Yu X.C., Yang J.J., Jin B.H., et al., A Strategy for Bypassing the Bloodbrain Barrier: Facial Intradermal Braintargeted Delivery via the Trigeminal Nerve, Journal of Controlled Release 258 (2017): 2233

Concordant with the hypothesis that biguanides activate SKN-1 metabolic/innate immune and not oxidative stress defenses, phenformin treatment reduces expression of the canonical oxidative stress response gene gst-4 irrespective of bacterial diet source (Figure 6figure supplement 1AB), while reciprocally inducing expression of the innate immune response gene dod-24 in a manner dependent both upon skn-1 and ether lipids (Figure 6F and Figure 6figure supplement 1C)