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One of the most landmark studies in this field, often referred to as the "Tomato Pill" trial, was a randomized, double-blind, placebo-controlled study conducted at the University of Cambridge in 2014

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Improved insights into key factors that influence the individual-specific response to antibiotics and dietary intervention may lead to better efficacy in reversing or preventing antibiotic-induced microbial dysbiosis as well as strategies for preventing cardiometabolic diseases

Preparation of diisopropyl tosyloxymethanephosphonate consists in the treatment of diisopropyl phosphite with paraformaldehyde and triethylamine followed by tosylation (Hol, 1993)