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doi: 10.1146/annurev-physiol-020911-153251

Development of a stable ERroGFP variant suitable for monitoring redox dynamics in the ER

External factors contributing to free radical production include normal aerobic respiration activates, smoking, environmental pollutants, polymorphonuclear leukocytes, macrophages, radiation, certain medications, pesticides, industrial solvents, and ozone
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[PubMed: 12196520] 787

This is called hormesis
