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The NF-B, PI3K/Akt and P38 (MAPK) specific pathways that are associated with disease progression were also checked using the Western blot technique

Although there is exploration of indirectly reflecting ferroptosis activity by detecting lipid peroxidation products such as MDA and 4-HNE, iron metabolism indicators, or GPX4 expression in joint fluid (Xia S

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Dallas et al., 2009

In clinical settings, DFO has been shown to inhibit ferroptotic cardiomyocyte death, improving cardiac function in patients with iron overload, while DFX protects hepatocytes by preventing iron-driven ferroptosis (104106)

For instance, pachymaran (PCP), the major constituent of Poria cocos , activates the Nrf2/ARE pathway, upregulates HO-1 and NQO1 gene expression, enhances intrinsic antioxidant capacity, and suppresses TLR4/NF-B signaling to reduce inflammatory mediator release (70)