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Although 5-HT does not directly cause neurotoxicity to neurons, it acts indirectly by regulating the release of DA in the central reward system (Thomas et al., 2010)

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Like that associated with blockade of Ca 2+ and Na + influx, inhibition of NKA with ouabain also reduces the extent of cytosolic Ca 2+ accumulation (Netticadan et al., 1999)