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The data currently available reflects findings on the individual components rather than this specific combination, with no established safety or efficacy for human or veterinary applications

Eur J Nutr 46:20412 Papakostas GI, Shelton RC, Zajecka JM, Etemad B, Rickels K, Clain A, Baer L, Dalton ED, Sacco GR, Schoenfeld D, Pencina M, Meisner A, Bottiglieri T, Nelson E, Mischoulon D, Alpert JE, Barbee JG, Zisook S, Fava M (2012) l-Methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials

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Additionally, low methylation levels of the 5-HT2A gene were observed in the saliva of patients with schizophrenia and bipolar disorder, highlighting the potential of peripheral DNA methylation studies to identify novel biomarkers ( As previously discussed, DNA methylation changes in schizophrenia-related genes are integral to disease pathogenesis