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These macrophages, instead of promoting antitumor immunity, suppress the immune response, reducing the efficacy of CpG-ODN treatment

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Intestines Interestingly, by using a mouse model of intestinal IRI, it was shown that protein levels of GPX4 were decreased at early timepoints after reperfusion, whereas the expression of PTGS2 was increased and treatment with liproxstatin-1 attenuated the decrease in GPX4 expression and reduced cyclooxygenase-2 expression

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