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It suppresses the production of T helper-1 (Th1) cytokines (IL2 and IFN) and Th2 cytokines (IL4 and IL10), reduces costimulatory molecule activity (CD28 on CD4 + T cell, the co-receptor B7-1 activity in macrophages and dendritic cells), inhibits NFkB activation, which is a key transcription factor involved in T cell receptor-mediated signaling, and downregulates inducible MHC (major histocompatibility complex) class II expression

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doi: 10.1016/j.nut.2011.08.013 228 MartarelliDVerdenelliMCScuriSCocchioniMSilviSCecchiniCet al

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Evidence for prolonged release of excitatory amino acids in severe human head trauma

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