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doi:10.1007/s11011-012-9324-8, PMID: 22718491 Morris G, Maes M (2012) Increased nuclear factor-B and loss of p53 are key mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

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This makes BPC-157s preclinical safety evaluation more dependent on empirical data which, as noted above, is limited in scope than on mechanism-based safety predictions

Transdermal Patches Transdermal formulations must ensure that the drug penetrates the skin and reaches systemic circulation [81]