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Integr Cancer Ther 2004

Each compound has its own risk profile based on its mechanism and the tissues it targets

WHY CREATININE INCREASES 1 DECREASED KIDNEY FILTRATION (most important cause) When GFR (glomerular filtration rate) falls: Less filtration Creatinine not excreted Accumulates in blood Causes: Chronic kidney disease Acute kidney injury Glomerulonephritis Diabetic nephropathy Hypertensive nephrosclerosis 2 PRE-RENAL CAUSES (low kidney blood flow) Renal perfusion filtration Examples: Dehydration Shock Heart failure Severe blood loss Sepsis 3 POST-RENAL CAUSES (urinary obstruction) Urine outflow blocked back pressure GFR Examples: Prostate enlargement Kidney stones Tumor Ureteric obstruction

It provides the "building blocks" your body needs to make its own

NAC includes a key cofactor of Selenium, which is an essential component of many enzymes and proteins that helps protect against cell damage and infections

doi: 10.1016/s0140-6736(68)92892-4