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If large future randomized controlled trials can confirm these findings and a population-wide algorithm could be created and applied, then the cumulative benefits across many conditions could be dramatic even if the measurable benefits of treatment are relatively small

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Treating cells with L-buthionine sulfoximine (BSO), an inhibitor that blocks the synthesis of GSH, renders neuronal SH-SY5Y cells expressing mutant valosin-containing protein (VCP) R487H more susceptible to oxidative stress (Hirano et al., 2015) and increases mutant SOD1 toxicity (Alvarez-Zaldiernas et al., 2016