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Curr Med Chem 26:18331848 Zhu C-B, Blakely RD, Hewlett WA (2006) The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters

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Additionally, SAMe has been shown to have antidepressant effects and may be useful in treating depression and anxiety disorders

This means the appetite suppression does not continue to increase proportionally with dose beyond a certain point

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