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(2023), which included 18 randomized controlled trials, revealed that supplementation of probiotics, prebiotics, and synbiotics in CKD patients could significantly lower C-reactive protein, IL-6, and IS and improved levels of high-density lipoprotein cholesterol in comparison to the control group, but had no substantial effect on p-CS, low-density lipoprotein, cholesterol, TNF-, triglyceride, albumin, hemoglobin, total cholesterol, phosphorus, calcium, or uric acid in the serum of the patients (Chen C

RR intervenes in the progression of cardiovascular and neurodegenerative diseases, diabetes, sepsis, and cancer through various targets and pathways

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Am J Physiol Cell Physiol 312:C47C55

As the pKa value of the conjugate acid increases, it signifies stronger basicity in the form of lower pKb values

doi: 10.1007/978-1-0716-3429-5_1 8 CampuzanoV.MonterminiL.LutzY.CovaL.HindelangC.JiralerspongS.et al
