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Wang K, Zhuang Y, Liu C, Li Y

Reduced inflammation and dryness are frequently reported benefits
The catechol O-methyltransferase inhibitor entacapone in the treatment of Parkinsons disease: personal reflections on a first-in-class drug development programme 40 years on
However, for some people with epilepsy, high doses of caffeine or other stimulants can lower the seizure threshold, making them more susceptible to seizures[224]
This combined approach validates experimental observations and accelerates discovery