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To address this question, Ristow et al
Another important disadvantage of cytolytic peptides is their nonspecific cytotoxicity, which was discussed in a study by Zhao et al
Similar to other oncogenes, HIF-1 increases HIF-1 stimulates SLC7A11 expression, facilitating the exchange of glutamine with cystine, elevating glutathione levels within tumor cells, preventing the accumulation of ROS within tumor cells and impeding the occurrence of ferroptosis in tumor cells [108, 109]
