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Allergic Reactions: When a dogs immune system identifies certain proteins or compounds as harmful, it releases histamines and inflammatory cytokines to neutralise the perceived threat, causing localised or systemic inflammation

doi: 10.2174/1389200211314060002
The protein zonulin helps to mediate this permeability as well.57 Tight junctions connect your intestinal cells, regulating the movement of water and other substances through your GI tract

The first evidence of the exploitation of this route was obtained by Sjlinder and Jonsson in human CD46 transgenic mice (Sjlinder and Jonsson, 2010)

10.1016/j.neuron.2005.05.010 86 MasliahE.RockensteinE.ManteM.CrewsL.SpencerB.AdameA.et al

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