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Importantly, it should be highlighted that in cases presenting anti-CRP antibodies, false-negative test results may be evident in case samples with poor washing, which can lead to immunocomplexes between CRP and anti-CRP antibodies, thus lowering free CRP levels in the final analyzed sample, and apart from such immunocomplexes, it was also discussed that CRP can bind to soluble receptors or exist in plasma microvehicles

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[PUBMED Abstract] Cherpelis BS, Haddad F, Messina J, et al.: Sentinel lymph node micrometastasis and other histologic factors that predict outcome in patients with thicker melanomas

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