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Metabolic dysfunctions, including accumulation of lipids like polyunsaturated fatty acids and cholesterol, are involved in the misfolding and aggregation of alpha-synuclein [194]

A 2021 Nature Communications study then showed that MOTS-c is induced by exercise and that treating mice, including animals started late in life, boosted running capacity and physical performance across young, middle-aged, and old groups [3]

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