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Structured programs incorporating reduced-calorie diets (typically 500-750 kcal/day deficit), increased physical activity (150 minutes of moderate-intensity exercise weekly for weight loss

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At week 208, mean weight loss in the semaglutide group analyzed as first on-treatment was 11.7% compared with 1.5% for the placebo group (Fig

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with GLP1-S2.4 mg for weight management: a randomised, controlled, phase 1b trial